The mouth is the gateway to the human body. Appropriate oral health maintenance is not only vital for mastication, pronunciation, and esthetics, but it also plays a key role in the prevention of systemic diseases. Scientific evidence indicates that bacteria are constantly present in the oral cavity, serving as one of the main etiologies of many oral diseases. Removal of bacterial plaque and control of oral biofilm are essential for the prevention and treatment of those diseases. Mechanical plaque control has been proven as an effective way to reduce bacterial plaque. The use of chemical plaque control in conjunction with mechanical plaque control has become more frequent. This review article provides insight into the mechanisms of action and the delivery formats of chemical plaque control, and included detailed information on each individual active agent. Recent evidence on chemical oral, dental, and peri-implant chemical plaque control is summarized.